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Jul 28, 2025

When evaluating the 2025 Honda Odyssey vs. 2025 Toyota Sienna, families will want roomy interiors, safety features, fuel efficiency, and comfort above all.

This head-to-head comparison helps parents decide which model fits their day-to-day life best; we contrast performance, seating, fuel use, and tech so you can pick confidently.

Engine and Fuel Efficiency

The 2025 Honda Odyssey uses a 3.5-liter V6 engine producing about 280 horsepower, along with around 22 mpg combined in most trims.

The 2025 Toyota Sienna comes only as a hybrid combining a 2.5-liter four-cylinder engine and electric motors, giving 245 horsepower.

Fuel economy tips toward the Sienna, especially in city driving and for parents who do many short trips. Highway numbers favor the Odyssey occasionally when cruising at steady speeds.

Interior, Seating, and Cargo

The Odyssey seats up to eight passengers; the second row offers Magic Slide seats for access flexibility. Families love how the cabin is configured.

The Sienna also seats seven or eight, depending on trim. Its sliding side doors and thoughtful space in the second and third rows make it appealing when car seats or booster seats are involved.

Cargo capacity behind all seats is larger in the Odyssey when fully occupied; maximum cargo room when rows are folded or stowed is generous in both vehicles.

However, designs differ in how easily seats stow or fold. Odysseys allow more passenger seat reconfiguration.

Safety, Technology, and Features

Toyota updated the 2025 Sienna with a new Advanced Rear Seat Reminder that senses passengers left behind in the back.

Odyssey adds modern infotainment updates: a larger 9-inch touchscreen, wireless phone integration, Apple CarPlay and Android Auto, wireless phone charging, and updated rear entertainment options.

The Sienna’s hybrid powertrain has the advantage of lower fuel use during stop-and-go traffic; AWD is available for extra grip in poor weather. This is an appealing option for families living in regions with snow or rain. 

Driving and Comfort

The Odyssey offers a smooth, composed ride over rough surfaces thanks to its finely tuned suspension, while highway travel remains quiet and comfortable. Top trims feature premium seating materials and a host of luxurious creature comforts.

The Sienna focuses on enhanced comfort for long journeys, with higher trims boasting amenities such as a built-in vacuum, fridge box, upgraded multimedia displays, and captain’s chairs. For 2025, the cabin materials have been noticeably upgraded, elevating the overall interior experience.

Costs and Ownership

The initial cost of base Odyssey trims is generally competitive, and maintenance on the non-hybrid V6 tends to be straightforward. However, fuel expenses can be higher in heavy city driving compared to hybrid models.

The Sienna hybrid carries a higher price in certain trims, especially when equipped with AWD or luxury features. Over time, lower fuel costs help offset the upfront investment, making it a smart choice for drivers with high mileage.

Which Fits Your Family Best?

If your routine involves many stop-and-go trips, tight parking lots, and frequent seat reconfiguration, the Odyssey may suit you better. 

Should fuel savings carry more weight, or AWD capability be a priority for winter or rugged roads, Sienna might be the right pick.

At Auto Kings, we offer pre-owned vehicles for sale in Bend, OR. Setting up a time to take a test drive is simple at our dealership. Experiencing each minivan first-hand helps reveal which one best fits your lifestyle. 

Checking out our impressive inventory lets you find an affordable option without compromising on features important for family needs. For more information, feel free to contact us anytime.